| CAS NO: | 101-31-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 289.37 |
|---|---|
| Formula | C17H23NO3 |
| CAS No. | 101-31-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 58 mg/mL (200.4 mM) |
| Water: <1 mg/mL | |
| Ethanol: 58 mg/mL (200.4 mM) | |
| Solubility (In vivo) | 30% Propylene glycol, 5% Tween 80, 65% D5W: 5 mg/mL |
| Synonyms | Daturine |
| In Vitro | In vitro activity: -hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively. Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells. S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%. |
|---|---|
| In Vivo | L-hyoscyamine (20 mg/kg) prolongs migrating myoelectric complex (MMC) cycle length from 17.6 min to 29.0 min in conscious rats. |
| Animal model | Rat |
| Formulation & Dosage | Dissolved in saline; 20 mg/kg; i.v. injection |
| References | Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8. |
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