Description: Epiberberine is a natural anticancer alkaloid isolated from Coptis chinensis with the potential for the treatment of diabetic disease., it acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. It stabilizes telomeric G4s and inhibits telomerase, specifically recognizing the hybrid-2 telomeric G4 predominant in physiologically relevant K+ solution and converts other telomeric G4 forms to hybrid-2. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways.

References: Drug Dev Res. 2016 Jun;77(4):163-70.

Related CAS : 889665-86-5 (Epiberberine Chloride); 6873-09-2 (Epiberberine)

纯度：≥98%

CAS：6873-09-2