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Floxuridine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Floxuridine图片
CAS NO:50-91-9
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)246.19
FormulaC9H11FN2O5
CAS No.50-91-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 49 mg/mL (199.0 mM)
Water: 49 mg/mL (199.0 mM)
Ethanol: 49 mg/mL (199.0 mM)
Other info

Chemical Name: 5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

InChi Key: ODKNJVUHOIMIIZ-RRKCRQDMSA-N

InChi Code: InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

SMILES Code: O=C1NC(C(F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O

Synonyms5-Fluorouracil 2'-deoxyriboside; NSC27640; NSC 27640; 5-fluorodeoxyuridine; Deoxyfluorouridine, FDUR, NSC-27640;FdUrD; floxuridin; fluorodeoxyuridine; fluorouridine deoxyribose; fluoruridine deoxyribose. FUDF. 5FUDR; FDUR; FUdR. WR138720.
实验参考方法
In Vitro

In vitro activity: Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5'-O-mono amino acid ester prodrugs. Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. Floxuridine significantly inhibits the uptake of both [(3)H]-inosine and [(3)H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon's capsule fibroblasts in vitro. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction.

In Vivo
Animal model
Formulation & Dosage
References

Mol Pharm. 2008 Sep-Oct;5(5):717-27; Cancer Treat Rep. 1987 Apr;71(4):381-9.