Phortress (also known as NSC-710305) is a novel and potent apoptosis stimulant and also a P450 CYP1A1-activated antitumor prodrug with the potential for the treatment of solid tumours. Phortress had no effect on HUVEC and MRCV cell proliferation and survival. Unlike paclitaxel and fumagillin, Phortress did not inhibit endothelial tube differentiation. Phortress therefore exhibits no in vitro anti-angiogenic activity. As expected, Phortress was cytotoxic to MCF7 breast cancer cells, but unexpectedly, Phortress was also potent against colorectal cancer cells in clonogenic survival and cell growth (growth curves but not MTS assay) end-points.

纯度：≥98%

CAS：741241-36-1