Moxonidine HCl (also known as BE5895; BDF5895) is a potent and selective agonist at the imidazoline receptor subtype 1, and is used as centrally active antihypertensive agent. Moxonidine can bind to both I1-imidazoline receptor (I1R) and α2-adrenergic receptor (α2AR). The selectivity of moxonidine for I1R is 33-fold over α2AR. Moxonidine plays its antihypertensive role in the central nervous system. It has a central site of action. It is shown no effect in pithed rats and in cats following spinal cord transaction. Moxonidine also reduces sympathetic outflow and lowers peripheral vascular resistence.

纯度：≥98%

CAS：75536-04-8