| CAS NO: | 51781-21-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 328.83 |
|---|---|
| Formula | C16H25ClN2O3 |
| CAS No. | 51781-21-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 65 mg/mL (197.7 mM) |
| Water: <1 mg/mL | |
| Ethanol: 65 mg/mL (197.7 mM) | |
| Other info | Chemical Name: 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride InChi Key: FYBXRCFPOTXTJF-UHFFFAOYSA-N InChi Code: InChI=1S/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H SMILES Code: CC(C)(C)NCC(COC1=CC=CC2=C1CCC(=O)N2)O.Cl |
| Synonyms | OPC 1085; Carteolol Hydrochloride ; Carteolol HCl; OPC-1085; OPC1085; Arteoptic; Cartrol; Mikelan; Abbott-43326; Hydrochloride, Carteolol; Monohydrochloride, Carteolol; |
| In Vitro | In vitro activity: Previous findings demonstrate that carteolol, unlike xamoterol, is a nonconventional partial agonist, which causes agonistic effects via interaction with the low-affinity propranolol-resistant site of β1-adrenoceptors and antagonistic actions by the high-affinity site of the same receptors. |
|---|---|
| In Vivo | Both 8-OH carteolol and carteolol suppressed the water-load induced intraocular pressure (IOP) rise in rabbits. 8-OH carteolol was more effective in suppressing water-load induced IOP rise in rabbits compared with carteolol on equimolar basis. Both 8-OH carteololand carteolol caused a significant decrease in IOP in monkeys. 8-OH carteolol was estimated to be more potent than carteolol in lowering IOP on equimolar basis in monkeys. |
| Animal model | Monkeys |
| Formulation & Dosage | N/A |
| References | J Pharmacol Exp Ther. 2005 Dec;315(3):1386-95; Int Ophthalmol. 1989 Jan;13(1-2):85-9. |
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