| CAS NO: | 959-24-0 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| Molecular Weight (MW) | 308.82 |
|---|---|
| Formula | C12H20N2O3S.HCl |
| CAS No. | 959-24-0 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 62 mg/mL (200.8 mM) |
| Water: 62 mg/mL (200.8 mM) | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride InChi Key: VIDRYROWYFWGSY-UHFFFAOYSA-N InChi Code: InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H SMILES Code: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl |
| Synonyms | MJ 1999; sotalol Hydrochloride; Sotalol Monohydrochloride; Sotalol HCL; Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob |
| In Vitro | In vitro activity: Sotalol hydrochloride is a potent and non-selective antagonist of β-adrenergic receptor. Sotalol is also an inhibitor of potassium channels with an IC50 value of ~1.2mM in HEK cell lines. |
|---|---|
| In Vivo | In vivo, Sotalol hydrochloride has shown to lengthen atrial and ventricular monophasic action potential duration in the intact dog heart during constant atrial pacing. |
| Animal model | |
| Formulation & Dosage | |
| References | J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67. |
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