Pravastatin (CS514) is a potent HMG-CoA
reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. It is
natural product isolated from cultures of Nocardia autotrophica.
Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl
coenzyme A reductase, the enzyme which catalyzes the conversion of
HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent
lowers plasma cholesterol and lipoprotein levels, and modulates immune
responses by suppressing MHC II on interferon gamma-stimulated,
antigen-presenting cells such as human vascular endothelial cells.
纯度:≥98%
CAS:81093-37-0