| CAS NO: | 175135-47-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 253.30 |
|---|---|
| Formula | C16H15NO2 |
| CAS No. | 175135-47-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 51 mg/mL (201.3 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 4-[(4-Methoxyphenyl)methoxy]benzeneacetonitrile InChi Key: QJEJLARVLKHYFW-UHFFFAOYSA-N InChi Code: InChI=1S/C16H15NO2/c1-18-15-6-4-14(5-7-15)12-19-16-8-2-13(3-9-16)10-11-17/h2-9H,10,12H2,1H3 SMILES Code: N#CCC1=CC=C(OCC2=CC=C(OC)C=C2)C=C1 |
| Synonyms | O4I1; O4I-1; O4I 1 |
| In Vitro | In vitro activity: O4I1 enhances Oct3/4 gene expression by approximately 2.5- and 4-fold at 10 μM and 20 μM, respectively, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation. Cell Assay: When treated the synthesized cDNA from RNA isolated from the HEK293 cells with 10 μM and 20 μM O4I1 for 72 hrs, the Oct3/4 mRNA levels increased about 2.5- and 4-fold respectively. In human adult primary fibroblast (HF) and human neonatal foreskin fibroblast (HFF) cell lines, treatment with 10 μM O4I1 increased the gene and protein expression level of Oct3/4 after 72 hrs incubation in HF cells and 7 days in HFF cells. The derivatives of O4I1 such as compound 2, showed a time-dependent activation of Oct3/4 and markedly elevated the efficiency of Oct3/4 induction. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | J Med Chem. 2015 Jun 25;58(12):4976-83. |
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