您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Mometasone furoate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Mometasone furoate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mometasone furoate图片
CAS NO:83919-23-7
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
Mometasone Furoate (formerly Sch 32088; Sch32088; SCH-32088) is a potent glucocorticoid receptor agonist and an approved anti-inflammatory drug used as a topical formulation to reduce inflammation of the skin or in the airways. As a topical corticosteroid, mometasone furoate has anti-inflammatory, antipruritic, and vasoconstrictive properties.
理化性质和储存条件
Molecular Weight (MW)521.43
FormulaC27H30Cl2O6
CAS No.83919-23-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 6 mg/mL (11.5 mM)
Water:<1 mg/mL
Ethanol:<1 mg/mL
Other infoChemical Name: (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
InChi Key: WOFMFGQZHJDGCX-ZULDAHANSA-N
InChi Code: InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
SMILES Code: O=C(C1=CC=CO1)O[C@]2(C(CCl)=O)[C@H](C)C[C@@]3([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4(Cl)[C@@H](O)C[C@]23C)=O
SynonymsSCH-32088; Sch 32088; mometasone furoate cream (0.1); Sch-32088; Sch32088;
实验参考方法
In Vitro

In vitro activity: Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response.


Kinase Assay: Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor. IC50 value: Target: glucocorticosteroid receptor Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma.

In VivoMometasone causes a decrease in the instances of nasal rubbing and an inhibition of this response is observed during the treatment period in rats. Mometasone (3 mg/kg) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested in mice. Mometasone, given an hour after the last allergen challenge, dose-dependently inhibits the allergen-induced increase in Penh with about a 10-fold loss of potency when compared with the pre-challenge treatment schedule. Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibits the increase of antigen-induced nasal rubbing even 6 hours after topical application, indicating that both drugs have a long-lasting effect. Mometasone furoate dose-dependently inhibits the elevated eosinophil numbers in the bronchoalveolar lavage fluid and lung tissues of sensitized, ovalbumin challenged mice. Mometasone furoate (33 mg/kg) reduces the percentage of CD44+ T-helper cells (activated/memory cells) to the levels observed in non-sensitized, ovalbumin-challenged mice.
Animal modelovalbumin-challenged mice
Formulation & Dosage3 mg/kg
ReferencesImmunopharmacol Immunotoxicol. 2006;28(3):491-500; Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8.