PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor. It acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element binding protein (CREB) pathway, exerting neuroprotection in an Alzheimer's disease (AD) model. References: Bartolome F, de la Cueva M, Pascual C, Antequera D, Fernandez T, Gil C, Martinez A, Carro E. Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition. Alzheimers Res Ther. 2018 Feb 20;10(1):24. doi: 10.1186/s13195-018-0352-4. PubMed PMID: 29458418; PubMed Central PMCID: PMC5819290.
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CAS:18741-24-7