Aegeline is a main alkaloid extracted from Aegle marmelos Correa collected in Yogyakarta Indonesia. Aegeline inhibited the histamine release from RBL-2H3 cells induced by DNP(24)-BSA. Aegeline showed strong inhibition when RBL-2H3 cells induced by Ca(2+) stimulants such as thapsigargin and ionomycin. Tthe inhibitory effects of aegeline on the histamine release from mast cells depended on the type of mast cell and also involved some mechanisms related to intracellular Ca(2+) signaling events via the same target of the action of thapsigargin or downstream process of intracellular Ca(2+) signaling in mast cells. References: Gautam S, Ishrat N, Singh R, Narender T, Srivastava AK. Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1. Eur J Pharmacol. 2015 Sep 5;762:419-29. doi: 10.1016/j.ejphar.2015.05.021. Epub 2015 Jun 20. PubMed PMID: 26102565.

纯度：≥98%

CAS：456-12-2