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VU0418506
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1330624-42-4
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

VU0418506 is a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4). VU0418506 has been characterized as having suitable in vivo pharmacokinetic properties in three preclinical safety species. References: Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ. Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11. doi: 10.1021/acschemneuro.6b00036. Epub 2016 Aug 5. PubMed PMID: 27441572; PubMed Central PMCID: PMC5073817.

纯度:≥98%

CAS:1330624-42-4