生物活性
Clomifene citrate (Serophene) is a selective estrogen receptor modulator. Clomifene citrate (Serophene) increases production of gonadotropins by inhibiting negative feedback on the hypothalamus. Clomifene citrate (Serophene) is used mainly for ovarian stimulation in female infertility due to anovulation (e.g., infertility in polycystic ovary syndrome). Therapeutically, clomifene citrate (Serophene) is given early in the menstrual cycle. Clomifene citrate (Serophene) is typically prescribed beginning on day 1, 3 or 5 and continuing for 5 days. By that time, FSH level is rising steadily, causing development of a few follicles. Follicles in turn produce the estrogen, which circulates in serum. Clomifene acts by inhibiting the action of estrogen on the pituitary.
化学数据
| 分子量 | 598.08 |
| 分子式 | C26H28ClNO.C6H8O7 |
| CAS号 | 50-41-9 |
| 纯度 | >98% |
| 溶解性（25°C） | DMSO 100 mg/mL |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存
常温运输及临时存放 |
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
储备液配制
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.672 mL | 8.3601 mL | 16.7202 mL |
| 5 mM | 0.3344 mL | 1.672 mL | 3.344 mL |
| 10 mM | 0.1672 mL | 0.836 mL | 1.672 mL |
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