Pfn1-IN-C1 is an inhibitor of Profilin1 (Pfn1). It has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo. References: Gau D, Lewis T, Mcdermott L, Wipf P, Koes D, Roy P. Structure-based virtual screening identifies small molecule inhibitor of the profilin1-actin interaction. J Biol Chem. 2017 Dec 27. pii: jbc.M117.809137. doi: 10.1074/jbc.M117.809137. [Epub ahead of print] PubMed PMID: 29282288.

纯度：≥98%

CAS：919010-46-1