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Noradrenaline bitartrate monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Noradrenaline bitartrate monohydrate图片
CAS NO:108341-18-0
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)337.28
FormulaC8H11NO3.C4H6O6.H2O
CAS No.108341-18-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 64 mg/mL (189.7 mM)
Water: 64 mg/mL (189.7 mM)
Ethanol: <1 mg/mL
Other info

Chemical Name: 1,2-Benzenediol, 4-((1R)-2-amino-1-hydroxyethyl)-, (2R,3R)-2,3-dihydroxybutanedioate hydrate

InChi Key: LNBCGLZYLJMGKP-LUDZCAPTSA-N

InChi Code: InChI=1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1

SMILES Code: OC1=CC=C([C@@H](O)CN)C=C1O.O=C(O)[C@H](O)[C@@H](O)C(O)=O.[H]O[H]

SynonymsLevophed; Norepinephrine bitartrate; NSC169106; Arterenol bitartrate; Levophed; Noradrenalin bitartrate; NSC-169106; NSC 169106; Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate
实验参考方法
In Vitro

In vitro activity: Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations’ and would, through an enhancement of ‘bottom-up’ information processing at the expense of irrelevant ‘top-down’ expectations, favor behavioral adjustment. Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects.

In Vivo
Animal model
Formulation & Dosage
References

Trends Neurosci. 2005 Nov;28(11):574-82.; Int Clin Psychopharmacol. 2003 Jul;18(4):191-202.