PF-06679142 (PF06679142) is a novel and potent AMPK activator with favorable pharmacokinetics (high oral absorption, low plasma clearance). It activates the α1β1γ1/α2β1γ1-isoforms of AMPK with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK, and shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3). It has the potential for treating obesity and diabetes.

纯度：≥98%

CAS：1467059-66-0