| CAS NO: | 94-07-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 167.21 |
|---|---|
| Formula | C9H13NO2 |
| CAS No. | 94-07-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 33 mg/mL (197.34mM) |
| Water: <1 mg/mL | |
| Ethanol: 2 mg/mL (12 mM) | |
| Other info | Chemical Name: (R,S)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol InChi Key: YRCWQPVGYLYSOX-UHFFFAOYSA-N InChi Code: InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3 SMILES Code: CNCC(O)C1=CC=C(O)C=C1 |
| Synonyms | Oxedrine; Synephrine (racemate); Synephrine (+/-); (+/-)-Synephrine |
| In Vitro | In vitro activity: Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells. |
|---|---|
| In Vivo | Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine |
| Animal model | Rats |
| Formulation & Dosage | 1 mg/kg; oral gavage |
| References | Int J Med Sci. 2012;9(7):527-38; Biochem Biophys Res Commun. 2012 Feb 24;418(4):720-4.; Jpn J Pharmacol. 2001 Feb;85(2):183-8. |
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