Apcin is a ligand of Cdc20 and a potent and competitive inhibitor of the E3 ligase activity anaphase-promoting complex/cyclosome (APC/C). It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding
to Cdc20 and preventing substrate recognition. Apcin occupes the
D-box-binding pocket on the side face of the WD40-domain and can prolong
mitosis.
纯度:≥98%
CAS:300815-04-7