AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50 = 3.1 and 4.5 μM, human and mouse, respectively). AP-18 inhibited cholinergic twitch responses evoked by electrical field stimulation of cholinergic nerves as well as contractions in response to acetylcholine and histamine in the guinea pig small intestine. AP-18 (30 μmol/l) blocked spontaneous contractions of longitudinal strips of human jejunum. References: Kunkler PE, Zhang L, Pellman JJ, Oxford GS, Hurley JH. Sensitization of the trigeminovascular system following environmental irritant exposure. Cephalalgia. 2015 Nov;35(13):1192-201. doi: 10.1177/0333102415574845. Epub 2015 Feb 27. PubMed PMID: 25724913.

纯度：≥98%

CAS：55224-94-7