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PF-04418948
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-04418948图片
CAS NO:1078166-57-0
规格:≥98%
包装与价格:
包装价格(元)
1mg电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)409.41
FormulaC23H20FNO5
CAS No.1078166-57-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 81 mg/mL (197.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other infoChemical Name: 1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid
InChi Key: LWJGMYMNSNVCEM-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
SMILES Code: O=C(C1(COC2=CC=C3C=C(OC)C=CC3=C2)CN(C(C4=CC=C(C=C4)F)=O)C1)O
SynonymsPF04418948; PF-04418948; PF 04418948; PF4418948; PF-4418948; PF 4418948.
实验参考方法
In Vitro

In vitro activity: PF-04418948 antagonizes the effects of butaprost and PGE2 on an EFS-induced contraction of the human myometrium, and antagonizes PGE2-induced relaxation of carbachol pre-contracted rings of mouse trachea. PF-04418948 competitively inhibits relaxations of murine and guinea pig trachea induced by ONO-AE1-259 and PGE2 respectively. PF-04418948 restores neutrophil extracellular traps (NETs) formation in neutrophils isolated from BMT mice or HSCT patients.


Kinase Assay: PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.

In VivoIn Rats, PF-04418948 (10 mg/kg, p.o.) reduces the mean cutaneous blood flow peak response and AUC0–60 by 41% and 61%, respectively.
Animal modelSprague Dawley rats
Formulation & DosageFormulated in 0.5% w/v methylcellulose + 0.1% v/v Tween 80 in purified water; 10 mg/kg; p.o.
ReferencesBr J Pharmacol. 2011 Dec;164(7):1847-56; Br J Pharmacol. 2013 Jan;168(1):129-38.