OUP-186 is a high affinity and human/rat species-selective histamine H3 receptor antagonist. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 μM (R)-(-)-α-methylhistamine (H3R agonist). OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells. References: Tanaka S, Sakaguchi M, Yoneyama H, Usami Y, Harusawa S. Histamine H(3) receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell lines. Biochem Biophys Res Commun. 2016 Nov 18;480(3):479-485. doi: 10.1016/j.bbrc.2016.10.077. Epub 2016 Oct 21. PubMed PMID: 27773822.

纯度：≥98%

CAS：1480830-24-7