ONO-2050297 is the first potent dual CysLT1 and CysLT2 antagonist with IC50 of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively. References: Itadani S, Takahashi S, Ima M, Sekiguchi T, Fujita M, Nakayama Y, Takeuchi J.
Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist. ACS Med Chem Lett.
2014 Oct 6;5(11):1230-4. doi: 10.1021/ml500298y. eCollection 2014 Nov 13. PubMed
PMID: 25408836; PubMed Central PMCID: PMC4233365.
纯度:≥98%
CAS:1637756-67-2