Omtriptolide (PG490-88) is a water soluble and prodrug form of triptolide which is a
diterpene triepoxide and an immunosuppresive agent extracted from the
Chinese herb Tripterygium wilfordii. Triptolide treatment at the
concentration of 15 nM inhibited the invasion and migration of ovarian
cancer cells SKOV3 and A2780. Triptolide inhibited MMP7 and MMP19
expression with a dose-dependent manner from 0 to 15 nM in ovarian
cancer cells. Triptolide also enhanced expression of the E-cadherin in
ovarian cancer cell, then, affected the migration and cell invation..
纯度:≥98%
CAS:195883-06-8