NSC368262 is a selective Stat3-family member inhibitor. NSC368262 alkylates Cys468 in Stat3. References: Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, Moore R, Gugiu G, Lee TD, Yip R, Chen Y, Jove R, Horne D, Williams JC. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS Chem Biol. 2011 May 20;6(5):432-43. doi: 10.1021/cb100253e. Epub 2011 Feb 16. PubMed PMID: 21226522; PubMed Central PMCID: PMC3098940.
纯度:≥98%
CAS:299421-08-2