NS-0011 is an inhibitor of CDK5 translocation which increases CDK5 accumulation in the nucleus, suppressing both cancer cell proliferation and xenograft tumorigenesis. References: Cao L, Zhou J, Zhang J, Wu S, Yang X, Zhao X, Li H, Luo M, Yu Q, Lin G, Lin H, Xie J, Li P, Hu X, Zheng C, Bu G, Zhang YW, Xu H, Yang Y, Huang C, Zhang J. Cyclin-dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Clin Cancer Res. 2015 Mar 15;21(6):1419-28. doi: 10.1158/1078-0432.CCR-14-1950. Epub 2015 Jan 21. PubMed PMID: 25609066.
纯度:≥98%
CAS:1076234-33-7