| CAS NO: | 562-10-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 25g | 电议 |
| Molecular Weight (MW) | 388.46 |
|---|---|
| Formula | C17H22N2O.C4H6O4 |
| CAS No. | 562-10-7 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 78 mg/mL (200.8 mM) |
| Water: 78 mg/mL (200.8 mM) | |
| Ethanol: | |
| Solubility (In vivo) | Chemical Name: butanedioic acid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine InChi Key: KBAUFVUYFNWQFM-UHFFFAOYSA-N InChi Code: InChI=1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8) SMILES Code: CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O |
| Synonyms | Doxylamine Succinate; Decapryn; Unisom; Evigoa D |
| In Vitro | In vitro activity: The effects of doxylamine (as the succinate salt) on microsomal enzyme activity and serum thyroid hormone levels are examined in B6C3F1 mice following dietary exposure for 7 or 15 days (0, 40, 375, 750, or 1500 ppm in diet, expressed as free base doxylamine). The results suggest that doxylamine is a phenobarbital-type inducer of liver microsomal cytochrome P450 in B6C3F1 mice, and consistent with the hypothesis that doxylamine increases the activity of those hepatic enzymes involved in T4 metabolism. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Toxicol Appl Pharmacol. 1996 Dec;141(2):584-94. |
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