| CAS NO: | 1609960-30-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 269.13 |
|---|---|
| Formula | C11H10Cl2N4 |
| CAS No. | 1609960-30-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 53 mg/mL (196.9 mM) |
| Water: <1 mg/mL | |
| Ethanol: 10 mg/mL (37.2 mM) | |
| Other info | Chemical Name: 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine InChi Key: URWCXPXBBITYLR-UHFFFAOYSA-N InChi Code: InChI=1S/C11H10Cl2N4/c1-15-9-5-8(16-11(14)17-9)6-3-2-4-7(12)10(6)13/h2-5H,1H3,(H3,14,15,16,17) SMILES Code: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1 |
| Synonyms | TH287; TH 287; TH-287. |
| In Vitro | In vitro activity: TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. Cell Assay: In U2OS and other cancer cell lines, TH287 treatment selectively and effectively kill cancer cells with less toxic to some primary or immortalized cells. U2OS cells treated with TH287 shows increase of 8-oxodG in DNA. The MTH1 inhibitor TH287 induces DNA damage and activates an ATM-p53-mediated death response and DNA repair in U2OS cells. |
|---|---|
| In Vivo | In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82μM. |
| Animal model | C57Bl/6 mice |
| Formulation & Dosage | Dissolved in 1% DMSO, 10% ethanol, 10% Chremophore EL and 10% Tween-80 and diluted with PBS; 5 mg/kg; i.p. injection. |
| References | Nature. 2014 Apr 10;508(7495):215-21; J Pharm Biomed Anal. 2015 Feb;104:1-11. |
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