生物活性
SL-327是MEK1和MEK2的选择性抑制剂（IC50值分别为0.18和0.22μM）；在体外阻断海马LTP。全身性给药后，体内的脑渗透剂会阻止大鼠的恐惧条件和学习，并在小鼠中产生神经保护作用。
Targets
| Target | Value |
| MEK1 | IC50: 0.18μM |
| MEK2 | IC50: 0.22μM |
| AP-1 | IC50: 2.03μM |
| PKC | IC50: >10μM |
| MKK3/p38MAPK | IC50: 21μM |
| ERK1 | IC50: >50μM |
| MKK4 | IC50: >100μM |
| JNK | IC50: >100μM |
化学数据
| 目录号 | A14137 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 335.4 |
| Formula | C16H12F3N3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 305350-87-2 |
| Synonyms | SL 327, SL327 |
| SMILES | C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F |
溶解度
| In vitro (25°C) | DMSO | 66 mg/mL (196.81 mM) |
| Water | Insoluble |
| Ethanol | 7 mg/mL (20.87 mM) |
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 29.82 mL | 149.08 mL | 298.15 mL |
| 0.5 mM | 5.96 mL | 29.82 mL | 59.63 mL |
| 1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
| 5 mM | 0.6 mL | 2.98 mL | 5.96 mL |
*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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