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AZD 7545
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD 7545图片
CAS NO:252017-04-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
AZD-7545,AZD7545
产品介绍

生物活性

AZD7545是PDHK2的新型选择性小分子抑制剂(PDH激酶2),对PDHK1和PDHK2的IC50分别为36.8 nM和6.4 nM。

靶点信息

PDHK2PDHK1
6.4 nM36.8 nM

化学数据

目录号A14157
作用机制Inhibitor (抑制剂)
M. Wt478.87
FormulaC19H18ClF3N2O5S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.252017-04-2
SynonymsAZD-7545,AZD7545
SMILESC[C@@](C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O

溶解度

In vitroDMSO92 mg/mL (192.12 mM)
WaterInsoluble
Ethanol92 mg/mL (192.12 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.88 mL104.41 mL208.82 mL
0.5 mM4.18 mL20.88 mL41.76 mL
1 mM2.09 mL10.44 mL20.88 mL
5 mM0.42 mL2.09 mL4.18 mL

*The above data is based on the productmolecular weight 478.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.