CAS NO: | 55294-15-0 |
包装: | 50mg, 100mg, 250mg |
规格: | ≥98% |
Muzolimine is pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects. References: Grima M, Michel B, Barthelmebs M, Stephan D, Imbs JL. The effects of muzolimine and urine from muzolimine-treated rats on Na+K+Cl- cotransport in Madin-Darby canine kidney cells. Eur J Pharmacol. 1991 Sep 17;202(2):137-42. PubMed PMID: 1802742. 2: Pohlmann-Eden B, Berlit P, Maibach EA, Gretz N. Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases. Acta Neurol Scand. 1991 Jan;83(1):41-4. PubMed PMID: 1849334. 3: Sastry CS, Suryanarayana MV, Tipirneni AS, Prasad TN. Spectrophotometric determination of muzolimine. Talanta. 1988 Nov;35(11):914-6. PubMed PMID: 18964644. 4: Planelles G, Meilhac B, Anagnostopoulos T. Effects of muzolimine on the late distal tubule of necturus kidney. J Pharmacol Exp Ther. 1988 Sep;246(3):1152-7. PubMed PMID: 3418514. 5: Tartagni F, Ortolani P, Degli Esposti D, Cervi V, Magnani B. [Effects of sequentially administered or combined muzolimine and furosemide on water and solute excretion: quantitative and qualitative aspects]. Recenti Prog Med. 1987 Nov;78(11):496-9. Italian. PubMed PMID: 3324236. 6: Pohlmann-Eden B, Berlit P, Bangert J, Gretz N. [Neuromyelopathy caused by treatment with muzolimine]. Dtsch Med Wochenschr. 1987 Jul 31;112(31-32):1238. German. PubMed PMID: 3608851. 7: Galletti F, Strazzullo P, Gagliardi R, Cirillo M, Siani A, Iacone R, Mancini M. Metabolic effects of long-term therapy with muzolimine and chlorthalidone in hypertension. Eur J Clin Pharmacol. 1987;33(5):515-7. PubMed PMID: 3428346. 8: Salerno L, Pepe S, Sallì L, Scalici G, Curiale B, Salvato F. [Muzolimine in liver cirrhosis and essential arterial hypertension]. Clin Ter. 1986 Jul 31;118(2):99-107. Italian. PubMed PMID: 3742982. 9: Licata G, Scaglione R, Parrinello G, Rini GB, Asta N. [Clinical and hemodynamic effects of medium-term treatment with muzolimine in subjects with essential arterial hypertension]. G Ital Cardiol. 1986 Jul;16(7):583-5. Italian. PubMed PMID: 3781147. 10: Geck P, Pfeiffer B. Inhibition of ion transport in Ehrlich cells by muzolimine. Naunyn Schmiedebergs Arch Pharmacol. 1986 Jul;333(3):323-9. PubMed PMID: 2429195. 1 Hannedouche T, Fillastre JP. [Success of muzolimine in the treatment of refractory edema syndromes]. Presse Med. 1986 Apr 26;15(17):802. French. PubMed PMID: 2940531. 12: Malatino LS, Fiore CE, Foti R, Greco G, Fargetta C, Tamburino G. Slow-release nifedipine associated with muzolimine in the treatment of mild to moderate essential hypertension. Am J Nephrol. 1986;6 Suppl 108-10. PubMed PMID: 3826145. 13: Bazzato G, Coli U, Landini S, Fracasso A, Righetto F, Scanferla F, Forte M, Morachiello P. Muzolimine vs. furosemide in nephrotic syndrome: further support of different carrier(s) operating for enteral absorption. Z Kardiol. 1985;74 Suppl 2:92-5. PubMed PMID: 4002811. 14: Bandiani G, Camaiora E, Nicolini MA, Perotta U. Muzolimine in patients on chronic hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). Z Kardiol. 1985;74 Suppl 2:84-7. PubMed PMID: 4002809. 15: Kirsten R, Molz KH, Tzonev I, Nelson K. Clinical evaluation of muzolimine and indapamide during treatment for essential hypertension. Z Kardiol. 1985;74 Suppl 2:66-72. PubMed PMID: 4002807. 16: Beneitez C. Muzolimine in the treatment of essential arterial hypertension not controlled with other antihypertensive drugs. Z Kardiol. 1985;74 Suppl 2:52-5. PubMed PMID: 4002805. 17: Verma SP, Taylor SH. Haemodynamic studies with muzolimine in left ventricular failure complicating acute myocardial infarction. Z Kardiol. 1985;74 Suppl 2:37-42. PubMed PMID: 4002803. 18: Salerno M, Di Salvo M, Furnari R, Vaccaro F, Licciardi S, Finocchiaro S. Comparison of muzolimine and furosemide in heart failure. Z Kardiol. 1985;74 Suppl 2:32-3. PubMed PMID: 4002801. 19: Kahles H, Ertl G, Riegger G, Liebau G, Kochsiek K. Muzolimine therapy in patients with congestive heart failure in comparison with furosemide pretreatment. Effect on digoxin plasma concentration. Z Kardiol. 1985;74 Suppl 2:24-6. PubMed PMID: 4002799. 20: Garthoff B. Beneficial effect of muzolimine in postischemic acute renal failure in rats. Z Kardiol. 1985;74 Suppl 2:171-4. PubMed PMID: 4002795.
纯度:≥98%
CAS:55294-15-0