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Muzolimine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:55294-15-0
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Muzolimine is pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects. References: Grima M, Michel B, Barthelmebs M, Stephan D, Imbs JL. The effects of muzolimine and urine from muzolimine-treated rats on Na+K+Cl- cotransport in Madin-Darby canine kidney cells. Eur J Pharmacol. 1991 Sep 17;202(2):137-42. PubMed PMID: 1802742. 2: Pohlmann-Eden B, Berlit P, Maibach EA, Gretz N. Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases. Acta Neurol Scand. 1991 Jan;83(1):41-4. PubMed PMID: 1849334. 3: Sastry CS, Suryanarayana MV, Tipirneni AS, Prasad TN. Spectrophotometric determination of muzolimine. Talanta. 1988 Nov;35(11):914-6. PubMed PMID: 18964644. 4: Planelles G, Meilhac B, Anagnostopoulos T. Effects of muzolimine on the late distal tubule of necturus kidney. J Pharmacol Exp Ther. 1988 Sep;246(3):1152-7. PubMed PMID: 3418514. 5: Tartagni F, Ortolani P, Degli Esposti D, Cervi V, Magnani B. [Effects of sequentially administered or combined muzolimine and furosemide on water and solute excretion: quantitative and qualitative aspects]. Recenti Prog Med. 1987 Nov;78(11):496-9. Italian. PubMed PMID: 3324236. 6: Pohlmann-Eden B, Berlit P, Bangert J, Gretz N. [Neuromyelopathy caused by treatment with muzolimine]. Dtsch Med Wochenschr. 1987 Jul 31;112(31-32):1238. German. PubMed PMID: 3608851. 7: Galletti F, Strazzullo P, Gagliardi R, Cirillo M, Siani A, Iacone R, Mancini M. Metabolic effects of long-term therapy with muzolimine and chlorthalidone in hypertension. Eur J Clin Pharmacol. 1987;33(5):515-7. PubMed PMID: 3428346. 8: Salerno L, Pepe S, Sallì L, Scalici G, Curiale B, Salvato F. [Muzolimine in liver cirrhosis and essential arterial hypertension]. Clin Ter. 1986 Jul 31;118(2):99-107. Italian. PubMed PMID: 3742982. 9: Licata G, Scaglione R, Parrinello G, Rini GB, Asta N. [Clinical and hemodynamic effects of medium-term treatment with muzolimine in subjects with essential arterial hypertension]. G Ital Cardiol. 1986 Jul;16(7):583-5. Italian. PubMed PMID: 3781147. 10: Geck P, Pfeiffer B. Inhibition of ion transport in Ehrlich cells by muzolimine. Naunyn Schmiedebergs Arch Pharmacol. 1986 Jul;333(3):323-9. PubMed PMID: 2429195. 1 Hannedouche T, Fillastre JP. [Success of muzolimine in the treatment of refractory edema syndromes]. Presse Med. 1986 Apr 26;15(17):802. French. PubMed PMID: 2940531. 12: Malatino LS, Fiore CE, Foti R, Greco G, Fargetta C, Tamburino G. Slow-release nifedipine associated with muzolimine in the treatment of mild to moderate essential hypertension. Am J Nephrol. 1986;6 Suppl 108-10. PubMed PMID: 3826145. 13: Bazzato G, Coli U, Landini S, Fracasso A, Righetto F, Scanferla F, Forte M, Morachiello P. Muzolimine vs. furosemide in nephrotic syndrome: further support of different carrier(s) operating for enteral absorption. Z Kardiol. 1985;74 Suppl 2:92-5. PubMed PMID: 4002811. 14: Bandiani G, Camaiora E, Nicolini MA, Perotta U. Muzolimine in patients on chronic hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). Z Kardiol. 1985;74 Suppl 2:84-7. PubMed PMID: 4002809. 15: Kirsten R, Molz KH, Tzonev I, Nelson K. Clinical evaluation of muzolimine and indapamide during treatment for essential hypertension. Z Kardiol. 1985;74 Suppl 2:66-72. PubMed PMID: 4002807. 16: Beneitez C. Muzolimine in the treatment of essential arterial hypertension not controlled with other antihypertensive drugs. Z Kardiol. 1985;74 Suppl 2:52-5. PubMed PMID: 4002805. 17: Verma SP, Taylor SH. Haemodynamic studies with muzolimine in left ventricular failure complicating acute myocardial infarction. Z Kardiol. 1985;74 Suppl 2:37-42. PubMed PMID: 4002803. 18: Salerno M, Di Salvo M, Furnari R, Vaccaro F, Licciardi S, Finocchiaro S. Comparison of muzolimine and furosemide in heart failure. Z Kardiol. 1985;74 Suppl 2:32-3. PubMed PMID: 4002801. 19: Kahles H, Ertl G, Riegger G, Liebau G, Kochsiek K. Muzolimine therapy in patients with congestive heart failure in comparison with furosemide pretreatment. Effect on digoxin plasma concentration. Z Kardiol. 1985;74 Suppl 2:24-6. PubMed PMID: 4002799. 20: Garthoff B. Beneficial effect of muzolimine in postischemic acute renal failure in rats. Z Kardiol. 1985;74 Suppl 2:171-4. PubMed PMID: 4002795.

纯度:≥98%

CAS:55294-15-0