NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate.
CAS：53-59-8
分子式：C21H28N7O17P3
分子量：743.4
纯度：98%
存储：Store at -20°C

Background:

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate(NADPH.Item No.ajce52358). It serves as a cofactor in various biological reactions.[1],[2] In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling.[2],[3] For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation.[4] NADP+ is biosynthesized from NAD+ (Item No.ajci18674) by NAD kinase, with ATP as the phosphoryl donor[5].

Reference:
[1]. Jackson, J.B. A review of the binding-change mechanism for proton-translocating transhydrogenase. Biochimica et Biophysica Acta 1817(10), 1839-1846 (2012).
[2]. Nakamura, M., Bhatnagar, A., and Sadoshima, J. Overview of pyridine nucleotides review series. Circ. Res. 111(5), 604-610 (2012).
[3]. Ziegler, M. A vital link between energy and signal transduction: Regulatory functions of NAD(P). FEBS Journal 272(18), 4561-4564 (2014).
[4]. Kilfoil, P.J., Tipparaju, S.M., Barski, O.A., et al. Regulation of ion channels by pyridine nucleotides. Circ. Res. 112(4), 721-741 (2013).
[5]. Shi, F., Li, Y., Li, Y., et al. Molecular properties, functions, and potential applications of NAD kinases. Acta Biochim. Biophys. Sin. (Shanghai) 41(5), 352-361 (2009).