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Impurity F of Calcipotriol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Impurity F of Calcipotriol图片
CAS NO:112875-61-3
规格:98%
分子量:641.13
包装与价格:
包装价格(元)
10mg电议
5mg电议
1mg电议

产品名称
卡泊三醇杂质F
产品介绍

Impurity F of Calcipotriol(卡泊三醇杂质F)

Impurity F of Calcipotriol是钙泊三醇的杂质,钙泊三醇是1,25-Dihydroxyvitamin D3类似物。
CAS:112875-61-3
分子式:C39H68O3Si2
分子量:641.13
纯度:98%
存储:Store at -20°C

Background:

Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value:Target:Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

参考文献:

[1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240. 

[2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829. 

[3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111 

[4]. Lise Binderup,, Erik Bramm. Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology. Volume 37, Issue 5, 1 March 1988, Pages 889-895