NMS-P715 analog is an inhibitor of MPS1, with an IC50 of 84 nM.
CAS：1202055-34-2
分子式：C35H42N8O3
分子量：622.76
纯度：98%
存储：Store at -20°C

Background:

NMS-P715 analog is an inhibitor of MPS1, with an IC50 of 84 nM.

NMS-P715 analog (Compound 14) is an inhibitor of MPS1, with an IC50 of 84 nM; also less active on Aur-A, CDK2/A and PLK1 (IC50, 1.45, >10, 0.237 uM). In addition, NMS-P715 analog shows inhibitory effect on human tumor cell line (A2780) with an IC50 of 150 nM.

参考文献:
[1]. Caldarelli M, et al. Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4507-11.