BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM.
CAS：120533-76-8
分子式：C24H25NO4
分子量：391.5
纯度：98%
存储：Store at -20°C

Background:

BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 uM, respectively). BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA , a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.