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Arimoclomol maleate(BRX-220)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Arimoclomol maleate(BRX-220)图片
CAS NO:289893-26-1
规格:98%
分子量:429.85
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Arimoclomolmaleate(BRX-220)是一种热休克蛋白(HSP)的共诱导剂。
CAS:289893-26-1
分子式:C18H24ClN3O7
分子量:429.85
纯度:98%
存储:Store at -20°C

Background:

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP).



The HSP coinducer Arimoclomol (BRX-220), administered for 5 d, has a protective effect against CCK-induced acute pancreatitis. Repeated CCK treatment results in the typical laboratory and morphological changes of experimentally induced pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased in the animals treated with Arimoclomol [1]. Arimoclomol is a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease[2].


[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.