E3 ligase Ligand-Linker Conjugates 49 包含用于 E3 泛素连接酶 cereblon (CRBN) 配体和 linker。E3 ligase Ligand-Linker Conjugates 49 可通过 PROTAC 技术合成 降解剂。
CAS:2351103-63-2
分子式:C31H44N4O11
分子量:648.7
纯度:98%
存储:Store at -20°C
Background:
E3 ligase Ligand-Linker Conjugates 49 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 49 can be used to design PROTAC degrader.
Cereblon
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.