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GNF351
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GNF351图片
CAS NO:1227634-69-6
规格:98%
分子量:411.5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
GNF351是一种芳基烃受体(AHR)拮抗剂。GNF351与结合到AHR的光亲和性AHR配体竞争,IC50为62nM。GNF351对小鼠或人角质形成细胞的毒性极小。
CAS:1227634-69-6
分子式:C24H25N7
分子量:411.5
纯度:98%
存储:Store at -20°C

Background:

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1]. IC50: 62 nM (aryl hydrocarbon receptor)[1]


GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes[1]. Cell Proliferation Assay[1] Cell Line: Human primary keratinocytes



[1]. van den Bogaard EH,et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.