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Verproside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Verproside图片
CAS NO:50932-20-2
规格:98%
分子量:498.43
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Verproside,一种从 Pseudolysimachion 属分离的梓醇衍生物环烯醚萜苷,通过 IKK/IκB 信号级联反应抑制 NF-κB 活化,抑制TNF-α 诱导的 MUC5AC 表达。Verproside具有有效的抗炎,抗氧化,抗伤害作用,并且在体内是一种有效的抗哮喘 /COPD 候选药物。
CAS:50932-20-2
分子式:C22H26O13
分子量:498.43
纯度:98%
存储:Store at -20°C

Background:

Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo[1]. NF-κB TNF-α IKK


Verproside (2.5-20 μM; for 2 hours) markedly reduces phosphorylation levels of IKKα/β, IκBα, and TAK1 in the 5-20 μM range[1]. Western Blot Analysis[1] Cell Line: NCI-H292 cells


Verproside (Intragastrically; 30 mg/kg; 48 hours) significantly reduces the immunoglobulin E (IgE) levels of verproside-treated mice[2]. Animal Model: Specific pathogen-free female BALB/c mice aged 8-10 weeks[2]


[1]. Lee SU, et al. Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells. Cytokine. 2016 Jan;77:168-75. [2]. Oh SR, et al. Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 2006 Jun;6(6):978-86. Epub 2006 Feb 10.