Roy-Bz是一种选择性的 PKCδ 激活剂。Roy-Bz通过诱导涉及半胱天冬酶-3活化的PKCδ依赖性的线粒体凋亡途径,有效地抑制结肠癌细胞的增殖。
CAS:1246304-91-5
分子式:C36H38O8
分子量:598.68
纯度:98%
存储:Store at -20°C
Background:
Roy-Bz is a selecive PKCδ activator. Roy-Bz potently inhibits the proliferation of colon cancer cells by inducing a PKCδ-dependent mitochondrial apoptotic pathway involving caspase-3 activation[1].
PKCδ[1]
[1]. Bessa C, et al. Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy. Cell Death Dis. 2018 Jan 18;9(2):23.