Amuvatinibhydrochloride(MP470hydrochloride)是一种多靶点受体酪氨酸激酶抑制剂，抑制c-Kit(D816V)，c-Kit(D816H)，c-Kit(V560G)，c-Kit(V654A)，PDGFRα(D842V)，PDGFRα(V561D)，IC50分别为950nM，10nM，34nM，127nM，81nM和
CAS：1055986-67-8
分子式：C23H21N5O3S.xHCl
分子量：
纯度：98%
存储：Store at -20°C

Background:

Amuvatinib hydrochloride (MP470 hydrochloride) is a multi-targeted receptor tyrosine kinases inhibitor, which inhibits c-Kit (D816V), c-Kit (D816H), c-Kit (V560G), c-Kit (V654A), PDGFRα (D842V), and PDGFRα (V561D) with IC50s of 950 nM, 10 nM, 34 nM, 127 nM, 81 nM, and 40 nM, respectively[1]. Antineoplastic activity[2].

MP470, a novel receptor tyrosine kinase (RTK) inhibitor has shown growth inhibitory activity against a variety of cancer cell lines. MP470 is effective on LNCaP and PC-3 cells with an IC50 of