PS372424，CXCL10 的三个氨基酸片段，是一种特异的人 CXCR3 激动剂，具有抗炎活性，它抑制 CXCR3 配体 CXCL10 与 CXCR3 受体的结合，IC50 值为 42 nM。
CAS：914291-61-5
分子式：C33H44N6O4
分子量：588.74
纯度：98%
存储：Store at -20°C

Background:

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM[1][2][3]. CXCR3

PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[1]. Western Blot Analysis[1] Cell Line: CXCR3+ T cells and CXCR3- T cells

[1]. BoyÉ K, et al. The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. Nat Commun. 2017 Nov 17;8(1):1571. [2]. O’Boyle G, et al. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4598-603. [3]. Stroke IL, et al. Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries. Biochem Biophys Res Commun. 2006 Oct 13;349(1):221-8.