Phenoxodiol是一种合成genestein的类似物，激活线粒体caspase系统，抑制XIAP(一个凋亡抑制剂)，使癌细胞对fas介导的凋亡敏感。Phenoxodiol还通过稳定可分裂复合物抑制DNA拓扑异构酶II，从而阻止DNA复制。Phenoxodiol 在细胞周期的G1/S期诱导细胞周期阻滞，通过独立于p53的方式上调p21WAF1。
CAS：81267-65-4
分子式：C15H12O3
分子量：240.25
纯度：98%
存储：Store at -20°C

Background:

Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2]. Caspase, DNA topoisomerase II[1][2].

[1]. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20. [2]. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110.