WR99210 是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂，IC50 为 Plasmodium falciparum)。
CAS：47326-86-3
分子式：C14H18Cl3N5O2
分子量：394.68
纯度：98%
存储：Store at -20°C

Background:

WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of Plasmodium falciparum strains[2]. IC50:<0.075 nM (DHFR)[1]

[1]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. [2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.