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Rilmenidine Phosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rilmenidine Phosphate图片
CAS NO:85409-38-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)278.24
FormulaC10H19N2O5P
CAS No.85409-38-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 55 mg/mL (197.67 mM)
Water: <1 mg/mL
Ethanol: 1 mg/mL warmed (3.59 mM)
SMILESC1CC1C(C2CC2)NC3=NCCO3.OP(=O)(O)O
SynonymsS 3341; S3341; S-3341
实验参考方法
In Vitro

In vitro activity: Rilmenidine phosphate is the water soluble form of Rilmenidine. It is an antihypertensive drug targets the imidazoline receptor.


Cell Assay: In Hep G2 cells treated with 0.5 mM oleic acid for 6 hours and 1μm Rilmenidine for 30 minutes, the oleic acid-induced lipid accumulation decreases. Stimulation of imidazoline I-1 receptor by Rilmenidine activated P38 to induce the expression of FXR.

In VivoMice fed with HFD (high fat diet) had improved hepatic steatosis following the administration of Rilmenidien through the activation of imidazoline I-1 receptor. Imidazoline receptors are involved in the bulbospinal regulation of blood pressure and affect peripheral stimulation. In hypertensive patients, Rilmenidine decreased blood pressure in a dose-dependent mater. In contrast with placebo, Rilmenidine had significantly lowered blood pressures. In addition, Rilmenidine had significantly less incidences of adverse effects than using other drugs for hypertension.
Animal model
Formulation & Dosage
References

Am J Hypertens. 1992 Apr;5(4 Pt 2):99S-105S; Annu Rev Pharmacol Toxicol. 1996;36:511-44; Cardiovasc Hematol Agents Med Chem. 2006 Jan;4(1):17-32; Naunyn Schmiedebergs Arch Pharmacol. 2012 Jan;385(1):51-6.