生物活性
Adriamycin是一种蒽环类抗生素，它通过插入DNA起作用，而最严重的副作用是危及生命的心脏损害。它通常用于治疗多种癌症，包括血液系统恶性肿瘤，多种类型的癌症和软组织肉瘤。
靶点信息
化学数据
| 目录号 | A10041 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 580.0 |
| Formula | C27H29NO11.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 25316-40-9 |
| Synonyms | Doxorubicin |
| SMILES | C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl |
溶解度
| In vitro | DMSO | Warmed: 88 mg/mL (151.72 mM) |
| Water | 18 mg/mL (31.03 mM) |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 17.24 mL | 86.21 mL | 172.41 mL |
| 0.5 mM | 3.45 mL | 17.24 mL | 34.48 mL |
| 1 mM | 1.72 mL | 8.62 mL | 17.24 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.45 mL |
*The above data is based on the productmolecular weight 580.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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