生物活性
Amonafide (AS1413)是一种DNA插入剂和拓扑异构酶II抑制剂，是治疗肿瘤疾病的抗肿瘤药物之一。
靶点信息
化学数据
| 目录号 | A10071 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 283.3 |
| Formula | C16H17N3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 69408-81-7 |
| Synonyms | AS1413, Xanafide, Quinamed |
| SMILES | CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N |
溶解度
| In vitro | DMSO | 51 mg/mL (179.99 mM) |
| Water | Insoluble |
| Ethanol | 4 mg/mL (14.11 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 35.3 mL | 176.49 mL | 352.98 mL |
| 0.5 mM | 7.06 mL | 35.3 mL | 70.6 mL |
| 1 mM | 3.53 mL | 17.65 mL | 35.3 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
*The above data is based on the productmolecular weight 283.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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