生物活性
AP24534 (Ponatinib)是有效的多激酶和pan-BCR-ABL抑制剂。
Targets
| Target | Value |
| Abl | IC50: 0.37nM |
| PDGFRα | IC50: 1.1nM |
| VEGFR2 | IC50: 1.5nM |
| FGFR1 | IC50: 2.2nM |
| c-Src | IC50: 5.4nM |
| c-Kit | IC50: 12.5nM |
| Insulin Receptor | IC50: >1μM |
| IGF-1R | IC50: >1μM |
| AuroraA | IC50: >1μM |
| CDK2/CyclinE | IC50: >1μM |
化学数据
| 目录号 | A10080 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 532.6 |
| Formula | C29H27F3N6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 943319-70-8 |
| Synonyms | Ponatinib |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5 |
溶解度
| In vitro (25°C) | DMSO | 30 mg/mL (56.33 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 1% CMC Na | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 18.78 mL | 93.88 mL | 187.76 mL |
| 0.5 mM | 3.76 mL | 18.78 mL | 37.55 mL |
| 1 mM | 1.88 mL | 9.39 mL | 18.78 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
*The above data is based on the productmolecular weight 532.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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