Zingibroside R1 是一种三萜皂苷，分离自 Panax japonicas C. A. Meyer 根部，显示出优异的抗肿瘤作用以及抗血管生成活性。Zingibroside R1 具有一些抗 HIV-1 活性。Zingibroside R1 对 EAT 细胞的 2-脱氧-D-葡萄糖 (2-DG) 的摄取具有抑制作用(IC50=91.3 μM)。
CAS：80930-74-1
分子式：C42H66O14
分子量：794.97
纯度：98%
存储：Store at -20°C

Background:

Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity[1].Zingibroside R1 possesses some anti-HIV-1 activity.Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC50=91.3 μM)[2]. IC50: 91.3 μM (2-DG uptake)[1]

[1]. Yoshizaki K, et al. Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). Chem Pharm Bull (Tokyo). 2013;61(3):344-50. Epub 2012 Dec 28 [2]. Hasegawa H, et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60 (3):240-3.