生物活性
BI6727 (Volasertib)是一种高效且选择性的polo样激酶（PLK）1抑制剂（在一组癌细胞系中，酶IC50 = 0.87 nM，EC50 = 11-37 nM）。
靶点信息
| PLK1 (Cell-free assay) | | | | |
| 0.87 nM | | | | |
化学数据
| 目录号 | A10135 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 618.8 |
| Formula | C34H50N8O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 755038-65-4 |
| Synonyms | Volasertib, BI-6727 |
| SMILES | CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C |
溶解度
| In vitro (25°C) | DMSO | Warmed: 19 mg/mL (30.7 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 4% DMSO+corn oil | 1 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 16.16 mL | 80.8 mL | 161.6 mL |
| 0.5 mM | 3.23 mL | 16.16 mL | 32.32 mL |
| 1 mM | 1.62 mL | 8.08 mL | 16.16 mL |
| 5 mM | 0.32 mL | 1.62 mL | 3.23 mL |
*The above data is based on the productmolecular weight 618.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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